Actimobacillus actinomycetemcomitans, Porphyromonas gingivalis에 대한 불화물과 클로르헥시딘의 병합효과
Combined effect of fluoride compounds and chlorhexidine on Actionobacillus acitinomycetemcomitans and Porphyromonas gingivalis
소속 상세정보
1김경환/1Kyoung Hwan Kim
1손재범/1김동기/2성진효/1Jae Bum Son/1Dong Kie Kim/2Jin Hyo Sung
KMID : 0355419990230040317
Abstract
-Abstract-
The purpose of this investigation was to evaluate the combined effect of fluoride
compounds and chlorhexidine digluconate on the periodontal pathogens and to determine
what kinds of fluoride compounds are more synergistic with chlorhexidine. We assigned
culture broths to 5 test groups by adding 1.32 mM Sodium fluoride(NaF), 0.66mM
Stannous fluoride(SnF2), 2.23 μM chlorhexidine digluconate, 1.32mM NaF＋2.23 μM
chlorhexidine digluconate and 0.66mM SnF2＋2.23μM chlorhexidine
digluconate and control group without fluoride and chlorhexidine. A.
actinomycetemcomitans, P. gingivalis 381 and P. gingivalis W50 were inoculated into six
groups(pH7.3) of culture broth, respectively. And then, 0.5㎖ aliquats were removed from
the test tubes at baseline and at 6 hour intervals for up to 24 hours. The colony
forming units were calculated after 96 hours incubation at 37℃ in an anaerobic chamber
and were used to construct the time-kill curves after logarithmic transformation. The
proton NMR(Nuclear Magnetic Resonance) spectra of the combined solutions were
analyzed to know whether chemical reactions occurred or not. Combined solutions of
chlorhexidine digluconate and SnF2 has significantly greater inhibitory
effect than NaF on the growth of periodontal pathogen with the same fluoride content at
the same pH. The proton NMR show us that chemical reactions between fluoride
compounds and chlorhexidine gluconate do not occur in mixed solutions, It is concluded
that combinations of chlorhexidine gluconate and fluoride compounds are recommended
to reduce the number of periodontal pathogens, and that the SnF2 is more
effective than NaF in reducing the number of microorganisms.
키워드
클로르헥시딘; 불화물; chlorhexidine ddigluconate; combined effect; fluoride compounds; A. actinomycetemcomitans; P. gingicvalis;
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